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  • Core Facilities

Core Facilities

The Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital is committed to providing scientists with a world-class technology infrastructure. Shared facilities and core laboratories provide investigators with access to tools and technologies they would otherwise have to seek out or develop on their own, usually at great cost.

The 344,000 square foot building includes shared lab support on each floor. Currently, the following nine Core laboratories are operational:
 

  • Bioinformatics Core
    Offers computational expertise for genomic, metabolomic, and proteomic research
     
  • High Throughput Behavioral Screening Core
    Performs small molecule and genetic screening services on a variety of well validated Drosophila (fruit fly) models of human neurological diseases.
     
  • Human Stem Cell and Neuronal Differentiation Core
    Provides expertise and equipment necessary to generate and experimentally manipulate human pluripotent stem cells and their differentiated progeny.
     
  • In vivo Neurophysiology Core
    Performs and offers training in rodent neurophysiological assays
     
  • Microscopy Core
    Offers expertise and access to the state-of-the-art fluorescence, confocal, two-photon and multi-photon laser-scanning microscopes.
     
  • NMR and Drug Metabolism Core
    Offers sophisticated NMR spectrophotometers and other tools to support the discovery, synthesis, screening, optimization, metabolism, and pharmacokinetics of small molecule ligands or lead compounds. 
     
  • Neuropathology Core
    Performs histological and immunohistochemical assays to facilitate neuropathological analyses of human and animal model tissues.
     
  • Optogenetics and Viral Vectors Core
    Provides access to technologies and reagents to perform neurotropic viral expression, optogenetic manipulation, and in vivo electrophysiological stimulation/recordings
     
  • RNA In situ Hybridization Core
    Performs non-radioactive RNA in situ hybridization assays on individual tissues and for high-throughput applications 
     
  • Rodent Neurobehavior Core
    Provides sophisticated behavioral analyses of rodent models